Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.31 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.31 |
| ▸ | RARA | P10276 | 1/20 | 0.30 |
| ▸ | RARB | P10826 | 1/20 | 0.30 |
| ▸ | RARG | P13631 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6642062 | 0.76 | PTGS1 (0.53) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6672311 | 0.76 | PTGS1 (0.53) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6668333 | 0.75 | PTGS1 (0.52) | PTGS2PTGS1 | |
| SCHEMBL6593328 | 0.71 | PTGS2 (0.62) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6671972 | 0.70 | PTGS1 (0.47) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6673352 | 0.70 | PTGS1 (0.53) | PTGS2PTGS1ALOX5 | |
| SCHEMBL8759810 | 0.70 | PTGS2 (1.00) | PTGS2PTGS1ALOX5 | |
| SCHEMBL8759670 | 0.68 | PTGS2 (0.86) | PTGS2PTGS1ALOX5 | |
| SCHEMBL8349771 | 0.68 | PTGS1 (0.45) | PTGS2PTGS1ALOX5 | |
| SCHEMBL13479401 | 0.67 | PTGS1 (0.39) | PTGS2PTGS1ALOX5GABBR2GABBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0904272-B1 | DIHYDROBENZOFURAN AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | UNIV VANDERBILT (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-0904272-A1 | DIHYDROBENZOFURAN AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | THE PROCTER & GAMBLE COMPANY (US) | 1999-03-31 | — | — | EP | disclosed |
| US-5686471-A | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents | THE PROCTER & GAMBLE COMPANY (US) | 1997-11-11 | — | — | US | disclosed |
| WO-1997028155-A1 | DIHYDROBENZOFURAN AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | THE PROCTER & GAMBLE COMPANY (US) | 1997-08-07 | — | — | WO | disclosed |