Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | NMT2 | O60551 | 1/20 | 0.55 |
| ▸ | NMT1 | P30419 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | CACNA1F | O60840 | 5/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 5/20 | 0.47 |
| ▸ | CACNA1S | Q13698 | 5/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7086519 | 0.91 | RXFP1 (0.56) | KDM4EHRH3MEN1KMT2ARXFP1 | |
| SCHEMBL5558555 | 0.86 | KDM4E (0.51) | KDM4EHRH3MEN1GAAKMT2A | |
| SCHEMBL5559235 | 0.85 | HRH3 (0.52) | KDM4EHRH3MEN1GAAKMT2A | |
| SCHEMBL3061600 | 0.80 | LMNA (0.49) | NMT2NMT1MEN1KMT2AALDH1A1 | |
| SCHEMBL6982551 | 0.79 | MAPK1 (0.49) | KDM4EHRH3PTPN1MEN1KMT2A | |
| SCHEMBL6983907 | 0.78 | KDM4E (0.60) | KDM4EHRH3ALDH1A1 | |
| SCHEMBL73410 | 0.77 | LMNA (0.68) | KDM4EMEN1KMT2ARXFP1ALDH1A1 | |
| SCHEMBL27297400 | 0.77 | KMT2A (0.53) | MEN1KMT2ATDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10593191 | 0.77 | PTPN1 (0.50) | KDM4ENMT2NMT1HRH3PTPN1 | |
| SCHEMBL9788513 | 0.76 | NMT2 (0.47) | KDM4ENMT2NMT1HRH3PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1093367-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-03-05 | — | — | EP | claimed |
| EP-1093367-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-25 | — | — | EP | claimed |
| WO-1999066925-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-29 | — | — | WO | claimed |
| EP-1093367-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1093367-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-25 | — | — | EP | disclosed |
| WO-1999066925-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-29 | — | — | WO | disclosed |