Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3974193 | 0.86 | ADAM17 (0.57) | SMN1; SMN2HTTMMP13ADAM17 | |
| SCHEMBL2528433 | 0.84 | NPC1 (0.51) | SMN1; SMN2HTTPKMRXFP1MAPK1 | |
| SCHEMBL6629881 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2HTTPKMRXFP1MAPK1 | |
| SCHEMBL6633283 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2HTTPKMRXFP1MAPK1 | |
| SCHEMBL6790022 | 0.78 | NCF1 (0.60) | SMN1; SMN2HTTCYP1A2NCF1ALDH1A1 | |
| SCHEMBL3967736 | 0.76 | CYP1A2 (0.54) | SMN1; SMN2HTTCYP1A2ADAM17NCF1 | |
| SCHEMBL6632245 | 0.75 | ADAM17 (0.63) | SMN1; SMN2HTTCYP1A2MMP13ADAM17 | |
| SCHEMBL7246568 | 0.73 | LMNA (0.44) | MMP13ADAM17ALDH1A1CASP1CASP7 | |
| SCHEMBL18535317 | 0.73 | CYP1A2 (0.58) | SMN1; SMN2HTTCYP1A2NCF1ALDH1A1 | |
| SCHEMBL3970289 | 0.72 | SMN1; SMN2 (0.47) | SMN1; SMN2HTTPKMRXFP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322627-A1 | CYCLIC SULFONYL COMPOUNDS AS INHIBITORS OF METALLOPROTEASES | Bristol-Myers Squibb Pharma Company (US) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002028846-A1 | CYCLIC SULFONYL COMPOUNDS AS INHIBITORS OF METALLOPROTEASES | DUPONT PHARMACEUTICALS COMPANY (US) | 2002-04-11 | — | — | WO | disclosed |