Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 17/20 | 0.72 |
| ▸ | MAPT | P10636 | 15/20 | 0.72 |
| ▸ | MEN1 | O00255 | 13/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.72 |
| ▸ | RAB9A | P51151 | 10/20 | 0.72 |
| ▸ | NPC1 | O15118 | 8/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 10/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.58 |
| ▸ | TP53 | P04637 | 7/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 7/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983615 | 0.82 | PPARA (0.60) | MAPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL12204416 | 0.78 | MAPT (0.67) | GAAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL11968855 | 0.75 | GAA (0.73) | GAAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL9547640 | 0.74 | GAA (0.72) | GAAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL11968803 | 0.74 | GAA (0.71) | GAAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL6983738 | 0.74 | MEN1 (0.60) | GAAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL6984029 | 0.74 | RAB9A (0.72) | MAPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL6973249 | 0.74 | MEN1 (0.68) | GAAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL6983832 | 0.74 | RAB9A (0.58) | GAAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL7748507 | 0.72 | GAA (0.64) | GAAMAPTMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030835-B1 | UREA DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | ASTRAZENECA UK LTD (GB) | 2003-01-22 | — | — | EP | disclosed |
| US-6344570-B1 | ANTISTICKING AGENTS FOR CELLS | ASTRAZENECA UK LIMITED (GB) | 2002-02-05 | — | — | US | disclosed |
| EP-1030835-A2 | UREA DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | AstraZeneca UK Limited (GB) | 2000-08-30 | — | — | EP | disclosed |
| WO-1999024398-A2 | UREA DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-05-20 | — | — | WO | disclosed |