Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.60 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CDK9 | P50750 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31054229 | 0.86 | PPARA (0.58) | PPARAGPR174EPHX2SMN1; SMN2TP53 | |
| SCHEMBL6983832 | 0.84 | RAB9A (0.58) | GPR174SMN1; SMN2KMT2AMEN1NPC1 | |
| SCHEMBL6973249 | 0.84 | MEN1 (0.68) | EPHX2SMN1; SMN2TP53CASP3SENP7 | |
| SCHEMBL6984029 | 0.84 | RAB9A (0.72) | TSHRCASP3SENP7KMT2AMEN1 | |
| SCHEMBL6983738 | 0.84 | MEN1 (0.60) | PPARAGPR174SMN1; SMN2CASP3SENP7 | |
| SCHEMBL6984539 | 0.82 | GAA (0.72) | SMN1; SMN2TP53CASP3SENP7KMT2A | |
| SCHEMBL1305413 | 0.80 | KMT2A (0.75) | PPARAGPR174EPHX2SMN1; SMN2TP53 | |
| SCHEMBL4104467 | 0.80 | MAPT (0.76) | PPARAGPR174SMN1; SMN2TP53KMT2A | |
| SCHEMBL7356599 | 0.80 | KMT2A (0.67) | SMN1; SMN2TSHRKMT2AMEN1RAB9A | |
| SCHEMBL7299454 | 0.80 | TP53 (0.68) | SMN1; SMN2TP53TSHRMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030835-B1 | UREA DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | ASTRAZENECA UK LTD (GB) | 2003-01-22 | — | — | EP | disclosed |
| US-6344570-B1 | ANTISTICKING AGENTS FOR CELLS | ASTRAZENECA UK LIMITED (GB) | 2002-02-05 | — | — | US | disclosed |
| EP-1030835-A2 | UREA DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | AstraZeneca UK Limited (GB) | 2000-08-30 | — | — | EP | disclosed |
| WO-1999024398-A2 | UREA DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-05-20 | — | — | WO | disclosed |