Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
| ▸ | GRM6 | O15303 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981189 | 0.84 | SLC7A5 (0.37) | KMT2AEPHX2SLC7A5GRM6ALDH1A1 | |
| SCHEMBL6984974 | 0.82 | SLC6A3 (0.40) | KMT2AEPHX2SLC7A5ALDH1A1LMNA | |
| SCHEMBL6981261 | 0.81 | SLC7A5 (0.37) | KMT2AEPHX2SLC7A5NR3C2MAPT | |
| SCHEMBL6984281 | 0.81 | SMN1; SMN2 (0.36) | EPHX2SLC7A5GRM6ALDH1A1SMN1; SMN2 | |
| SCHEMBL17374993 | 0.80 | KMT2A (0.49) | KMT2AGRM6CES2CES1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL30822606 | 0.79 | KMT2A (0.48) | KMT2AGRM6CES2CES1ALDH1A1 | |
| SCHEMBL6723581 | 0.77 | ELANE (0.44) | KMT2ASLC7A5ALDH1A1LMNAMAPT | |
| SCHEMBL6977356 | 0.77 | MRGPRX1 (0.35) | EPHX2SLC7A5GRM6ALDH1A1LMNA | |
| SCHEMBL6984283 | 0.77 | SLC7A5 (0.38) | KMT2AEPHX2SLC7A5GRM6ALDH1A1 | |
| SCHEMBL6985172 | 0.76 | AR (0.36) | KMT2AEPHX2SLC7A5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289953-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1289950-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001096304-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |
| WO-2001096296-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |