SCHEMBL6984619

SCHEMBL6984619

Cc1c(C)c2c(c(C)c1N)CC(C)(CN1CCC(C(=O)NC(c3ccccc3)c3ccccc3)CC1)O2

nearest known ligand 0.42

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.42
DRD2 P14416 5/20 0.38
OPRM1 P35372 1/20 0.36
OPRD1 P41143 1/20 0.36
CCR5 P51681 2/20 0.35
TP53 P04637 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
ALDH1A1 P00352 1/20 0.34
RECQL P46063 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6975786 0.90 POLB (0.40) LMNATP53SMN1; SMN2ALDH1A1
SCHEMBL6985201 0.87 EPHX2 (0.45) LMNADRD2SMN1; SMN2ALDH1A1
Hydrochloric Acid SCHEMBL6978492 0.86 EPHX2 (0.45) LMNADRD2SMN1; SMN2ALDH1A1
SCHEMBL6976347 0.84 CHRM1 (0.32)
SCHEMBL6983686 0.84 CHRM1 (0.32)
SCHEMBL6980124 0.84 CHRM1 (0.32)
Hydrochloric Acid SCHEMBL6980788 0.84 CHRM1 (0.31)
Sulfuric Acid SCHEMBL6985648 0.83 MGLL (0.31)
Sulfuric Acid SCHEMBL6984280 0.83 MGLL (0.31)
Sulfuric Acid SCHEMBL6984275 0.83 MGLL (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0923575-B1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-03-12 EP disclosed
US-6172085-B1 CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-01-09 US disclosed
EP-0923575-A1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS Takeda Chemical Industries, Ltd. (JP) 1999-06-23 EP disclosed
WO-1998008842-A1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-03-05 WO disclosed