Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 17/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR1F | P30939 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | CYP3A43 | Q9HB55 | 1/20 | 0.41 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983023 | 0.92 | UTS2R (0.45) | UTS2ROPRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7143857 | 0.88 | SLC6A2 (0.43) | UTS2RSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL6979203 | 0.87 | SLC6A2 (0.43) | UTS2RSLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL6984730 | 0.85 | UTS2R (0.44) | UTS2RHTR1ACYP2D6DRD2HTR1D | |
| SCHEMBL6981912 | 0.78 | REN (0.44) | UTS2RSLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL6983020 | 0.77 | UTS2R (0.45) | UTS2RSLC6A2SLC6A4MBTPS1 | |
| SCHEMBL6985336 | 0.73 | UTS2R (0.43) | UTS2RSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL6597663 | 0.72 | SLC6A4 (0.42) | UTS2RSLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL7143855 | 0.72 | SLC6A2 (0.40) | UTS2RSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL6979200 | 0.72 | UTS2R (0.43) | UTS2RSLC6A2SLC6A4SLC6A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246619-A4 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| EP-1246619-A1 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001045700-A1 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-06-28 | — | — | WO | disclosed |