Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 10/20 | 0.39 |
| ▸ | MMP2 | P08253 | 9/20 | 0.39 |
| ▸ | MMP8 | P22894 | 6/20 | 0.39 |
| ▸ | MMP13 | P45452 | 3/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.37 |
| ▸ | MMP3 | P08254 | 6/20 | 0.37 |
| ▸ | APP | P05067 | 2/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | FCER2 | P06734 | 1/20 | 0.32 |
| ▸ | MMP7 | P09237 | 2/20 | 0.31 |
| ▸ | MMP9 | P14780 | 3/20 | 0.31 |
| ▸ | MMP10 | P09238 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | MMP14 | P50281 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6986337 | 0.99 | MMP1 (0.38) | MMP1MMP2MMP8MMP13ADAM17 | |
| SCHEMBL6980963 | 0.81 | MMP1 (0.36) | MMP1MMP2MMP8MMP13ADAM17 | |
| SCHEMBL6982654 | 0.81 | MMP1 (0.52) | MMP1MMP2MMP8MMP13ADAM17 | |
| SCHEMBL6981622 | 0.76 | ADAM17 (0.68) | MMP1MMP2MMP8MMP13ADAM17 | |
| Hydrochloric Acid SCHEMBL6986451 | 0.75 | ADAM17 (0.67) | MMP1MMP2MMP8MMP13ADAM17 | |
| Hydrochloric Acid SCHEMBL6982157 | 0.74 | ADAM17 (0.64) | MMP1MMP2MMP8MMP13ADAM17 | |
| SCHEMBL7377058 | 0.73 | HDAC7 (0.46) | MMP1MMP2MMP8MMP13ADAM17 | |
| SCHEMBL6983510 | 0.73 | ADAM17 (0.52) | MMP1MMP2MMP8MMP13ADAM17 | |
| SCHEMBL9714087 | 0.70 | MMP1 (0.41) | MMP1MMP2MMP8MMP13ADAM17 | |
| Hydrochloric Acid SCHEMBL6986409 | 0.68 | ADAM17 (0.68) | MMP1MMP2MMP8MMP13ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |