Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 5/20 | 0.52 |
| ▸ | MMP13 | P45452 | 2/20 | 0.52 |
| ▸ | MMP8 | P22894 | 3/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.43 |
| ▸ | FCER2 | P06734 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 5/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 5/20 | 0.39 |
| ▸ | MMP7 | P09237 | 3/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980442 | 0.87 | MMP1 (0.42) | MMP1MMP13MMP8ADAM17FCER2 | |
| SCHEMBL6984793 | 0.81 | MMP1 (0.39) | MMP1MMP13MMP8ADAM17FCER2 | |
| SCHEMBL6981622 | 0.80 | ADAM17 (0.68) | MMP1MMP13MMP8ADAM17FCER2 | |
| SCHEMBL6985193 | 0.80 | MMP1 (0.50) | MMP1MMP13MMP8ADAM17FCER2 | |
| Hydrochloric Acid SCHEMBL6986337 | 0.80 | MMP1 (0.38) | MMP1MMP13MMP8ADAM17FCER2 | |
| SCHEMBL7855580 | 0.79 | MMP1 (0.62) | MMP1MMP13MMP8FCER2TSHR | |
| Hydrochloric Acid SCHEMBL6986451 | 0.79 | ADAM17 (0.67) | MMP1MMP13MMP8ADAM17FCER2 | |
| SCHEMBL6983149 | 0.79 | MMP2 (0.37) | MMP1MMP13MMP8TSHRMMP2 | |
| SCHEMBL6982089 | 0.79 | MMP1 (0.47) | MMP1MMP13MMP8ADAM17FCER2 | |
| SCHEMBL6941577 | 0.78 | MMP1 (0.50) | MMP1MMP13MMP8ADAM17FCER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |