Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.36 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | EPM2A | O95278 | 1/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PRNP | P04156 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984802 | 0.81 | MAPT (0.54) | CYP2A6MAPTTBXAS1PFKFB3PFKFB4 | |
| SCHEMBL6118386 | 0.77 | ALDH1A1 (0.41) | MAPTKMT2AMEN1PRNPSMN1; SMN2 | |
| SCHEMBL4655134 | 0.76 | CYP2A6 (0.47) | CYP2A6PFKFB3PFKFB4PTPN1EPM2A | |
| SCHEMBL4654001 | 0.75 | PIM1 (0.34) | CYP2A6MAPTTBXAS1PFKFB3PFKFB4 | |
| SCHEMBL4939687 | 0.74 | MCL1 (0.40) | CYP2A6MAPTTBXAS1SMN1; SMN2LMNA | |
| SCHEMBL4655071 | 0.74 | MAPT (0.36) | CYP2A6MAPTTBXAS1PFKFB3PFKFB4 | |
| SCHEMBL8110812 | 0.72 | PFKFB3 (0.39) | CYP2A6PFKFB3PFKFB4PTPN1EPM2A | |
| SCHEMBL12431301 | 0.72 | ROCK1 (0.44) | CYP2A6PFKFB3PFKFB4PTPN1EPM2A | |
| SCHEMBL10857945 | 0.72 | CYP2A6 (0.42) | CYP2A6PFKFB3PFKFB4PTPN1EPM2A | |
| SCHEMBL4654028 | 0.72 | PFKFB3 (0.38) | MAPTTBXAS1PFKFB3PFKFB4PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044061-A2 | BENZOTHIOPHENE INHIBITORS OF RHO KINASE | Kahraman, Mehmet (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008011560-A2 | BENZOTHIOPHENE INHIBITORS OF RHO KINASE | KAHRAMAN MEHMET (US) | 2008-01-24 | — | — | WO | disclosed |
| US-20080021026-A1 | BENZOTHIOPHENE INHIBITORS OF RHO KINASE | Kahraman, Mehmet (US) | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021026-A1 | BENZOTHIOPHENE INHIBITORS OF RHO KINASE | RHOT2, ROCK2, ROCK1 | CYP2A6 4122/4885MAPT 551/4885TBXAS1 338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.