Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 3/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.33 |
| ▸ | BCKDK | O14874 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984802 | 0.81 | MAPT (0.54) | KDM4EMAPTCYP2A6TBXAS1PIM1 | |
| SCHEMBL2552331 | 0.77 | PTGS2 (0.41) | CYP2A6MCL1 | |
| SCHEMBL19299978 | 0.71 | MCL1 (0.57) | KDM4EMAPTKEAP1NFE2L2TBXAS1 | |
| SCHEMBL10431976 | 0.69 | CYP2A6 (0.47) | KDM4EMAPTCYP2A6PIM1PIM2 | |
| SCHEMBL13226866 | 0.69 | MAPT (0.42) | KDM4EMAPTCYP2A6KEAP1NFE2L2 | |
| SCHEMBL3928426 | 0.69 | CYP2A6 (0.41) | MAPTCYP2A6TBXAS1PIM1PIM2 | |
| SCHEMBL3686803 | 0.68 | KDM4E (0.46) | KDM4ECYP2A6ROCK1CMA1NPSR1 | |
| SCHEMBL17256196 | 0.67 | LOXL2 (0.62) | KDM4EMAPTMCL1RXFP1L3MBTL1 | |
| SCHEMBL5090711 | 0.67 | BCKDK (0.44) | KDM4EMAPTCYP2A6KEAP1NFE2L2 | |
| SCHEMBL9404660 | 0.67 | KDM4E (0.41) | KDM4EMAPTCYP2A6PIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044061-A2 | BENZOTHIOPHENE INHIBITORS OF RHO KINASE | Kahraman, Mehmet (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008011560-A2 | BENZOTHIOPHENE INHIBITORS OF RHO KINASE | KAHRAMAN MEHMET (US) | 2008-01-24 | — | — | WO | disclosed |