Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698661 | 0.85 | ELANE (0.43) | ELANEMEN1KMT2ACYP19A1ALDH1A1 | |
| SCHEMBL6986198 | 0.81 | TDP1 (0.54) | MEN1KMT2AALDH1A1ACHETSHR | |
| SCHEMBL5756711 | 0.79 | OPRM1 (0.43) | ELANEOPRM1OPRK1CYP19A1ALDH1A1 | |
| SCHEMBL6982155 | 0.78 | OPRM1 (0.57) | OPRM1OPRK1ACHE | |
| SCHEMBL5754953 | 0.76 | CYP3A4 (0.54) | ELANEMEN1KMT2AALDH1A1ACHE | |
| SCHEMBL9909016 | 0.75 | ELANE (0.59) | ELANEMEN1KMT2AALDH1A1ACHE | |
| SCHEMBL12469648 | 0.75 | ELANE (0.59) | ELANEMEN1KMT2AALDH1A1ACHE | |
| SCHEMBL5755376 | 0.75 | OPRM1 (0.50) | OPRM1OPRK1CHRM2CHRM3 | |
| SCHEMBL14564780 | 0.73 | CYP19A1 (0.43) | ELANEMEN1KMT2ACYP19A1ALDH1A1 | |
| SCHEMBL2885533 | 0.72 | BACE1 (0.53) | CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030207876-A1 | 3-Azabicyclo[3.1.0]hexane derivatives useful in therapy | PFIZER, INC. | 2003-11-06 | — | — | US | disclosed |
| EP-1292574-A1 | 3-AZABICYCLO[3.1.0]HEXANE DERIVATIVES HAVING OPIOID RECEPTOR AFFINITY | PFIZER INC. (US) | 2003-03-19 | — | — | EP | disclosed |
| US-20020025948-A1 | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy | PFIZER INC. | 2002-02-28 | — | — | US | disclosed |
| WO-2001098267-A1 | 3-AZABICYCLO (3.1.0) HEXANE DERIVATIVES HAVING OPIOID RECEPTOR AFFINITY | PFIZER LIMITED (GB) | 2001-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207876-A1 | 3-Azabicyclo[3.1.0]hexane derivatives useful in therapy | OPRD1, OPRK1, OPRM1 | ELANE 601/4885MEN1 4567/4885KMT2A 3458/4885 |
| US-20020025948-A1 | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy | OPRD1, OPRK1, OPRM1 | ELANE 601/4885MEN1 4567/4885KMT2A 3458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.