Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.39 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | ANPEP | P15144 | 2/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | LAP3 | P28838 | 1/20 | 0.34 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.34 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942458 | 0.89 | ADAM17 (0.37) | RENCAPN1ATMKMT2AMAPK1 | |
| SCHEMBL6943368 | 0.89 | ADAM17 (0.37) | RENCAPN1ATMKMT2AMAPK1 | |
| SCHEMBL6983531 | 0.86 | REN (0.41) | RENATMMAPK1MMP2 | |
| SCHEMBL6986700 | 0.86 | PSMB5 (0.36) | RENCAPN1ATMKMT2AMAPK1 | |
| SCHEMBL6981635 | 0.85 | MAPT (0.35) | RENATMKMT2AMAPK1MEN1 | |
| SCHEMBL6979636 | 0.85 | ADAM17 (0.35) | RENCAPN1ATMKMT2AMAPK1 | |
| SCHEMBL6985082 | 0.83 | CTSS (0.35) | RENATMKMT2AMAPK1ADAM17 | |
| SCHEMBL6986589 | 0.83 | PSMB5 (0.34) | RENATMKMT2AMAPK1MMP9 | |
| SCHEMBL6221981 | 0.81 | REN (0.37) | RENATMKMT2AMAPK1MEN1 | |
| SCHEMBL6219848 | 0.80 | REN (0.36) | RENATMKMT2AMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |