Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.46 |
| ▸ | TACR2 | P21452 | 11/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6747828 | 0.86 | CTSL (0.47) | CTSK | |
| SCHEMBL6987702 | 0.85 | ALDH1A1 (0.41) | TACR2 | |
| SCHEMBL6751639 | 0.83 | CTSL (0.50) | CTSK | |
| SCHEMBL6749622 | 0.82 | CTSB (0.42) | CTSK | |
| SCHEMBL6747732 | 0.81 | CTSL (0.40) | CTSKTACR2 | |
| SCHEMBL6747702 | 0.81 | CTSL (0.44) | CTSK | |
| SCHEMBL6752286 | 0.81 | CTSL (0.51) | CTSK | |
| SCHEMBL6751875 | 0.81 | CTSB (0.46) | CTSK | |
| SCHEMBL6751305 | 0.80 | GRIA2 (0.40) | — | |
| SCHEMBL6747821 | 0.80 | CTSL (0.39) | CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362042-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057249-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |