Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 7/20 | 0.49 |
| ▸ | TNFRSF1A | P19438 | 6/20 | 0.44 |
| ▸ | SMPD3 | Q9NY59 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.39 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.39 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.39 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.39 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.39 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7058562 | 0.84 | TNFRSF1A (0.57) | ERN1TNFRSF1AMAPTTUBB4ATUBB | |
| SCHEMBL6989732 | 0.81 | TNFRSF1A (0.61) | ERN1TNFRSF1AMAPTKDM4EMEN1 | |
| SCHEMBL6989022 | 0.77 | TNFRSF1A (0.50) | ERN1TNFRSF1AMAPTTUBB4ATUBB | |
| SCHEMBL6990108 | 0.75 | TNFRSF1A (0.60) | ERN1TNFRSF1AKDM4EMEN1ALDH1A1 | |
| SCHEMBL5576239 | 0.73 | TNFRSF1A (0.68) | TNFRSF1A | |
| SCHEMBL5576244 | 0.73 | TNFRSF1A (0.68) | TNFRSF1A | |
| SCHEMBL27574433 | 0.73 | ERN1 (0.46) | ERN1TNFRSF1ASMPD3MAPTTUBB4A | |
| SCHEMBL14546651 | 0.71 | ALDH1A1 (0.51) | ERN1TNFRSF1AMAPTTUBB4ATUBB | |
| SCHEMBL5560733 | 0.70 | TNFRSF1A (0.57) | ERN1TNFRSF1AMAPTRXFP1KDM4E | |
| SCHEMBL2780877 | 0.70 | RPS6KB2 (0.56) | ERN1TNFRSF1ASMPD3MAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1330448-A2 | 1,3-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND THEIR USE TO TREAT VCAM-1 MEDIATED DISORDERS | Atherogenics, Inc. (US) | 2003-07-30 | — | — | EP | disclosed |
| WO-2003033662-A2 | PROTECTION AGAINST OXIDATIVE STRESS AND INFLAMMATION BY A CYTOPROTECTIVE RESPONSE ELEMENT | ATHEROGENICS, INC. (US) | 2003-04-24 | — | — | WO | disclosed |
| WO-2001098291-A2 | 1,3-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND THEIR USE TO TREAT VCAM-1 MEDIATED DISORDERS | ATHEROGENICS, INC. (US) | 2001-12-27 | — | — | WO | disclosed |