Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 12/20 | 0.60 |
| ▸ | ERN1 | O75460 | 3/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986840 | 0.83 | TNFRSF1A (0.65) | TNFRSF1AKDM4EALDH1A1 | |
| SCHEMBL4628631 | 0.78 | TNFRSF1A (0.60) | TNFRSF1AERN1MEN1KMT2AKDM4E | |
| SCHEMBL7062708 | 0.77 | TNFRSF1A (0.50) | TNFRSF1AERN1MEN1KMT2AKDM4E | |
| SCHEMBL6988312 | 0.76 | TNFRSF1A (0.44) | TNFRSF1AERN1 | |
| SCHEMBL7121640 | 0.76 | TNFRSF1A (0.64) | TNFRSF1AHDAC1HDAC2RAB9A | |
| SCHEMBL5575668 | 0.75 | TNFRSF1A (1.00) | TNFRSF1A | |
| SCHEMBL5575661 | 0.75 | TNFRSF1A (1.00) | TNFRSF1A | |
| SCHEMBL6985223 | 0.75 | ERN1 (0.49) | TNFRSF1AERN1ABCB1ABCC1MEN1 | |
| SCHEMBL6990105 | 0.74 | TNFRSF1A (0.60) | TNFRSF1AERN1KDM4EL3MBTL1RAB9A | |
| SCHEMBL6093064 | 0.73 | TNFRSF1A (0.52) | TNFRSF1AABCB1ABCC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1330448-A2 | 1,3-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND THEIR USE TO TREAT VCAM-1 MEDIATED DISORDERS | Atherogenics, Inc. (US) | 2003-07-30 | — | — | EP | claimed |
| WO-2001098291-A2 | 1,3-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND THEIR USE TO TREAT VCAM-1 MEDIATED DISORDERS | ATHEROGENICS, INC. (US) | 2001-12-27 | — | — | WO | claimed |