Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1239372 | 0.89 | MAPT (0.54) | DRD2DRD4MAPTKDM4EALDH1A1 | |
| SCHEMBL30031901 | 0.89 | MAPT (0.54) | DRD2DRD4MAPTKDM4EALDH1A1 | |
| SCHEMBL2558649 | 0.86 | DRD2 (0.47) | DRD2DRD4MAPTKDM4EALDH1A1 | |
| SCHEMBL29952229 | 0.85 | GFER (0.43) | DRD2DRD4MAPTKDM4EALDH1A1 | |
| SCHEMBL12927835 | 0.85 | GFER (0.43) | DRD2DRD4MAPTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL29956266 | 0.83 | GFER (0.42) | DRD2DRD4MAPTKDM4EALDH1A1 | |
| SCHEMBL2563484 | 0.82 | TRIM24 (0.45) | DRD2DRD4MAPTKDM4EALDH1A1 | |
| SCHEMBL22982721 | 0.81 | DRD2 (0.53) | DRD2DRD4MAPTKDM4EALDH1A1 | |
| SCHEMBL2003000 | 0.81 | DRD2 (0.53) | DRD2DRD4MAPTKDM4EALDH1A1 | |
| SCHEMBL18885192 | 0.78 | KDM4E (0.44) | MAPTKDM4EALDH1A1MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367653-B2 | Azetidinyl diamides as monoacylglycerol lipase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2013-02-05 | — | — | US | claimed |
| EP-2421851-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2012-02-29 | — | — | EP | claimed |
| US-20100324013-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-23 | — | — | US | claimed |
| WO-2010124102-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | claimed |
| CN-101437817-A | Novel process for production of 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]-ethyl}-6-chloro-1,3-dihydro-2H-indol-2-one (ziprasidone) | RICHTER GEDEON NYRT (HU) | 2009-05-20 | — | — | CN | claimed |
| WO-2023179366-A1 | OXADIAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | 星希尔生物科技(上海)有限公司 | 2023-09-28 | — | — | WO | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| EP-3252050-B1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-02-26 | — | — | EP | disclosed |
| EP-2945943-B1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |
| CN-107849047-A | Biphenyl derivative, preparation method and medical application thereof | 四川海思科制药有限公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-105102429-A | N-haloalkylindoline intermediates, process and use in preparation of silodosin and derivatives thereof | MANKIND RES CT | 2015-11-25 | — | — | CN | disclosed |
| CN-102643221-B | Silodosin intermediate and preparation method thereof | ZHEJIANG JIUZHOU PHARM CO LTD | 2015-02-11 | — | — | CN | disclosed |
| EP-0976731-A4 | PROCESS FOR PRODUCING 5-METHYLINDOLINES | IHARA CHEMICAL IND CO (JP) | 2000-05-24 | — | — | EP | disclosed |
| US-6066744-A | Process for producing 5-methylindolines | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2000-05-23 | — | — | US | disclosed |
| EP-0976731-A1 | PROCESS FOR PRODUCING 5-METHYLINDOLINES | Ihara Chemical Industry Co., Ltd. (JP) | 2000-02-02 | — | — | EP | disclosed |
| CN-1045777-C | Tetracyclic derivatives, preparation method and use | ACOS INC (US) | 1999-10-20 | — | — | CN | disclosed |
| CN-1224720-A | Tetracylic derivatives, process of preparation and use | ICOS CORP (US) | 1999-08-04 | — | — | CN | disclosed |
| WO-1998045261-A1 | PROCESS FOR PRODUCING 5-METHYLINDOLINES | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 1998-10-15 | — | — | WO | disclosed |
| CN-1143963-A | Tetracyclic derivatives, preparation method and use | GLAXO LAB SA (FR) | 1997-02-26 | — | — | CN | disclosed |
| CN-1059725-A | Novel methotrexate derivatives | CHUGAI PHARMACEUTICAL CO LTD (JP) | 1992-03-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324013-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | PNLIP, LPL, LIPA | DRD2 865/4885DRD4 1937/4885MAPT 4519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.