Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 6/20 | 0.35 |
| ▸ | BCHE | P06276 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.35 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL6980644 | 0.92 | GRM5 (0.42) | BCHESLC6A2SLC6A4SLC6A3GRM5 | |
| SCHEMBL6983930 | 0.88 | CHRM2 (0.43) | BCHESLC6A2SLC6A4SLC6A3GRM5 | |
| Oxalic Acid SCHEMBL6983672 | 0.84 | BCHE (0.43) | BCHESLC6A2SLC6A4SLC6A3GRM5 | |
| Oxalic Acid SCHEMBL6977629 | 0.81 | SLC6A4 (0.39) | SLC6A2SLC6A4SLC6A3 | |
| Oxalic Acid SCHEMBL6984815 | 0.79 | SLC6A4 (0.50) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6978239 | 0.79 | SLC6A4 (0.37) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6979549 | 0.79 | CHRM2 (0.44) | BCHESLC6A2SLC6A4SLC6A3GRM5 | |
| Oxalic Acid SCHEMBL6980816 | 0.78 | SLC6A4 (0.45) | SLC6A2SLC6A4SLC6A3 | |
| Oxalic Acid SCHEMBL6981322 | 0.77 | HRH1 (0.32) | — | |
| SCHEMBL6976596 | 0.76 | KCNA3 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923575-B1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-12 | — | — | EP | disclosed |
| US-6172085-B1 | CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-09 | — | — | US | disclosed |