Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 9/20 | 0.48 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985524 | 1.00 | PLA2G2A (0.48) | PLA2G2AHTR6TSHR | |
| SCHEMBL819415 | 0.92 | PLA2G2A (0.51) | PLA2G2AHTR6 | |
| SCHEMBL29862597 | 0.92 | PLA2G2A (0.51) | PLA2G2AHTR6 | |
| SCHEMBL818729 | 0.92 | PLA2G2A (0.51) | PLA2G2AHTR6 | |
| SCHEMBL29862369 | 0.92 | PLA2G2A (0.51) | PLA2G2AHTR6 | |
| SCHEMBL29862401 | 0.86 | PLA2G2A (0.53) | PLA2G2AHTR6 | |
| SCHEMBL818313 | 0.86 | PLA2G2A (0.53) | PLA2G2AHTR6 | |
| SCHEMBL6699396 | 0.85 | PLA2G2A (0.48) | PLA2G2AHTR6 | |
| SCHEMBL6983468 | 0.85 | HTR6 (0.51) | PLA2G2AHTR6 | |
| SCHEMBL6694888 | 0.85 | HTR6 (0.51) | PLA2G2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839806-B1 | Substituted tricyclics | LILLY CO ELI (US) | 2003-07-09 | — | — | EP | disclosed |
| EP-0839806-A1 | Substituted tricyclics | ELI LILLY AND COMPANY (US) | 1998-05-06 | — | — | EP | disclosed |