Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.45 |
| ▸ | FPR2 | P25090 | 4/20 | 0.41 |
| ▸ | FPR3 | P25089 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5842374 | 0.99 | HTR7 (0.50) | HTR7HTR6SIGMAR1FPR2FPR3 | |
| SCHEMBL6985304 | 0.89 | SIGMAR1 (0.46) | HTR7SIGMAR1TMEM97 | |
| SCHEMBL6986230 | 0.88 | SIGMAR1 (0.45) | HTR7SIGMAR1TP53TMEM97 | |
| Hydrochloric Acid SCHEMBL5842852 | 0.88 | SIGMAR1 (0.45) | HTR7SIGMAR1TMEM97 | |
| SCHEMBL6987164 | 0.88 | SIGMAR1 (0.46) | HTR7SIGMAR1TMEM97 | |
| Hydrochloric Acid SCHEMBL5841049 | 0.87 | SIGMAR1 (0.49) | HTR7SIGMAR1TMEM97 | |
| Hydrochloric Acid SCHEMBL5840920 | 0.87 | SIGMAR1 (0.44) | HTR7SIGMAR1TP53TMEM97 | |
| Hydrochloric Acid SCHEMBL5841184 | 0.87 | SIGMAR1 (0.46) | HTR7SIGMAR1TMEM97 | |
| SCHEMBL6985961 | 0.85 | HRH3 (0.47) | HTR7SIGMAR1 | |
| SCHEMBL5841500 | 0.85 | MEN1 (0.45) | HTR7SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |