Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5841184 | 0.99 | SIGMAR1 (0.46) | SIGMAR1TMEM97ABCB1HTR7 | |
| SCHEMBL6985304 | 0.89 | SIGMAR1 (0.46) | SIGMAR1TMEM97HTR7 | |
| SCHEMBL6986230 | 0.88 | SIGMAR1 (0.45) | SIGMAR1TMEM97HTR7 | |
| Hydrochloric Acid SCHEMBL5842852 | 0.88 | SIGMAR1 (0.45) | SIGMAR1TMEM97HTR7 | |
| SCHEMBL6985826 | 0.88 | HTR7 (0.51) | SIGMAR1TMEM97HTR7 | |
| SCHEMBL6987136 | 0.87 | SIGMAR1 (0.50) | SIGMAR1HTR7 | |
| Hydrochloric Acid SCHEMBL5840920 | 0.87 | SIGMAR1 (0.44) | SIGMAR1TMEM97HTR7 | |
| Hydrochloric Acid SCHEMBL5842374 | 0.87 | HTR7 (0.50) | SIGMAR1TMEM97HTR7 | |
| Hydrochloric Acid SCHEMBL5841049 | 0.87 | SIGMAR1 (0.49) | SIGMAR1TMEM97HTR7 | |
| Hydrochloric Acid SCHEMBL5842025 | 0.86 | SIGMAR1 (0.49) | SIGMAR1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |