Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 9/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3157560 | 0.98 | ALDH1A1 (0.48) | ALDH1A1EGLN3TBXAS1TDP1FAAH | |
| SCHEMBL6735760 | 0.87 | ALDH1A1 (0.43) | ALDH1A1EGLN3TBXAS1TDP1FAAH | |
| SCHEMBL28561099 | 0.80 | ALDH1A1 (0.38) | ALDH1A1EGLN3TBXAS1 | |
| SCHEMBL10997783 | 0.80 | EGLN3 (0.53) | ALDH1A1EGLN3TBXAS1TDP1 | |
| SCHEMBL11463256 | 0.79 | EGLN3 (0.45) | ALDH1A1EGLN3TBXAS1TDP1 | |
| SCHEMBL28249615 | 0.78 | ALDH1A1 (0.46) | ALDH1A1EGLN3TBXAS1TDP1 | |
| Hydrochloric Acid SCHEMBL28672413 | 0.77 | ALDH1A1 (0.44) | ALDH1A1EGLN3TBXAS1TDP1 | |
| SCHEMBL8032072 | 0.77 | TBXAS1 (0.57) | ALDH1A1EGLN3TBXAS1TDP1 | |
| SCHEMBL8761373 | 0.77 | — | — | |
| Bromide SCHEMBL28355066 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |