Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CES1 | P23141 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MYOC | Q99972 | 1/20 | 0.43 |
| ▸ | BCL9 | O00512 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983973 | 0.83 | F2 (0.50) | KMT2AMEN1MAPTHTTLMNA | |
| SCHEMBL28750884 | 0.82 | HTR2A (0.48) | HTR2AKMT2AMEN1MAPTNPC1 | |
| SCHEMBL8770261 | 0.82 | HTR2A (0.45) | HTR2AKMT2AMEN1MAPTNPC1 | |
| SCHEMBL6194967 | 0.77 | MEN1 (0.55) | KMT2AMEN1MAPTNPC1RAB9A | |
| SCHEMBL31144660 | 0.73 | CA1 (0.53) | HTR2AKMT2AMEN1MAPTNPC1 | |
| SCHEMBL11582009 | 0.73 | HSPB1 (0.53) | HTR2AKMT2AMEN1MAPTNPC1 | |
| SCHEMBL12991933 | 0.73 | MAPT (0.58) | KMT2AMEN1MAPTNPC1RAB9A | |
| SCHEMBL8331626 | 0.72 | GAA (0.53) | HTR2AKMT2AMEN1MAPTNPC1 | |
| SCHEMBL16671852 | 0.72 | GAA (0.57) | HTR2AKMT2AMEN1MAPTNPC1 | |
| SCHEMBL16922669 | 0.72 | GAA (0.57) | HTR2AKMT2AMEN1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292585-A1 | BENZOXAZEPINONES AND THEIR USE AS SQUALENE SYNTHASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001098282-A1 | BENZOXAZEPINONES AND THEIR USE AS SQUALENE SYNTHASE INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD (JP) | 2001-12-27 | — | — | WO | disclosed |