Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | DDX3X | O00571 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28069455 | 0.87 | LMNA (0.48) | F2LMNAALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL28226986 | 0.85 | TP53 (0.50) | F2TSHRLMNACES2CES1 | |
| SCHEMBL27590431 | 0.83 | F2 (0.46) | F2ALDH1A1CHRNB2CHRNA4MAPT | |
| SCHEMBL6986077 | 0.83 | HTR2A (0.46) | LMNACES2CES1MEN1KMT2A | |
| SCHEMBL6197458 | 0.81 | TSHR (0.55) | F2TSHRLMNACES2CES1 | |
| SCHEMBL20299326 | 0.75 | TSHR (0.52) | F2TSHRLMNACES2CES1 | |
| SCHEMBL28265959 | 0.75 | CHRNB2 (0.50) | F2TSHRLMNACES2CES1 | |
| SCHEMBL7671999 | 0.74 | TSHR (0.55) | F2TSHRLMNACES2CES1 | |
| SCHEMBL657614 | 0.73 | ALDH1A1 (0.59) | F2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL27679166 | 0.73 | ALDH1A1 (0.59) | F2LMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292585-A1 | BENZOXAZEPINONES AND THEIR USE AS SQUALENE SYNTHASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001098282-A1 | BENZOXAZEPINONES AND THEIR USE AS SQUALENE SYNTHASE INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD (JP) | 2001-12-27 | — | — | WO | disclosed |