Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KYNU | Q16719 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4505807 | 0.83 | HTT (0.56) | LMNAHTTGAAMAPTSMN1; SMN2 | |
| SCHEMBL3739983 | 0.82 | HDAC4 (0.57) | LMNAHTTGAAMAPTSMN1; SMN2 | |
| SCHEMBL31362087 | 0.80 | MEN1 (0.45) | LMNAHIF1AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL18530335 | 0.75 | PARP1 (0.52) | LMNAHIF1AKDM4EGAATSHR | |
| SCHEMBL8365159 | 0.74 | PARP1 (0.43) | LMNAGAASMN1; SMN2PARP1CNR1 | |
| SCHEMBL28038711 | 0.73 | KMT2A (0.54) | LMNAGAAHDAC4HDAC7HDAC5 | |
| SCHEMBL5843644 | 0.73 | LMNA (0.48) | LMNAHIF1AKDM4EGAAHDAC4 | |
| SCHEMBL10411665 | 0.73 | ADRB1 (0.49) | LMNAHIF1AKDM4EGAATSHR | |
| SCHEMBL443291 | 0.72 | MEN1 (0.47) | LMNAHIF1AKDM4EHTTMAPT | |
| SCHEMBL18557600 | 0.72 | KYNU (0.51) | LMNAHIF1AKDM4EHDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322617-A1 | COMPOUNDS AND METHODS FOR MODULATION OF ESTROGEN RECEPTORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024653-A1 | COMPOUNDS AND METHODS FOR MODULATION OF ESTROGEN RECEPTORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2002-03-28 | — | — | WO | disclosed |