Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | ELANE | P08246 | 2/20 | 0.39 |
| ▸ | CTSG | P08311 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986196 | 1.00 | P2RX4 (0.40) | P2RX4SMN1; SMN2CYP2C19NPC1RAB9A | |
| SCHEMBL6991071 | 0.76 | PARP1 (0.48) | SMN1; SMN2NPC1RAB9AF2ELANE | |
| SCHEMBL29380426 | 0.76 | PARP1 (0.48) | SMN1; SMN2NPC1RAB9AF2ELANE | |
| SCHEMBL7566815 | 0.76 | PARP1 (0.48) | SMN1; SMN2NPC1RAB9AF2ELANE | |
| SCHEMBL6991074 | 0.76 | PARP1 (0.48) | SMN1; SMN2NPC1RAB9AF2ELANE | |
| SCHEMBL7566816 | 0.76 | PARP1 (0.48) | SMN1; SMN2NPC1RAB9AF2ELANE | |
| SCHEMBL6230309 | 0.70 | P2RX4 (0.45) | P2RX4SMN1; SMN2CYP2C19NPC1RAB9A | |
| SCHEMBL6989538 | 0.69 | MTNR1B (0.49) | SMN1; SMN2NPC1RAB9ANPSR1ALDH1A1 | |
| SCHEMBL6989536 | 0.69 | MTNR1B (0.49) | SMN1; SMN2NPC1RAB9ANPSR1ALDH1A1 | |
| SCHEMBL1526556 | 0.67 | HTR2C (0.46) | SMN1; SMN2NPC1RAB9AF2ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649626-B1 | Stimulants of gamma -aminobutyric acid receptors; psychological disorders | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2003-11-18 | — | — | US | disclosed |
| EP-1224182-B1 | N-SUBSTITUTED 1-(BUTYROLACTONE)-ISOQUINOLINES FOR TREATING NERVOUS DISORDERS | CENTRE NAT RECH SCIENT (FR) | 2003-07-16 | — | — | EP | disclosed |