Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617937 | 0.85 | GPR119 (0.38) | GPR119HRH1DRD3HTR2AEGLN2 | |
| SCHEMBL6620971 | 0.84 | HRH1 (0.41) | HRH1DRD3LMNAHTR2ACNR1 | |
| SCHEMBL6621239 | 0.83 | EPHX2 (0.43) | GPR119HRH1EGLN2ARHRH2 | |
| SCHEMBL6622255 | 0.82 | GPR119 (0.49) | GPR119HRH1EGLN2HRH2EPHX2 | |
| SCHEMBL6733555 | 0.82 | PDE4B (0.39) | GPR119EGLN2EPHX2 | |
| SCHEMBL6739016 | 0.81 | FAAH (0.44) | HRH1DRD3LMNAHTR2ACNR1 | |
| SCHEMBL6621851 | 0.79 | CETP (0.44) | GPR119EGLN2EPHX2 | |
| SCHEMBL6622413 | 0.79 | KCNH2 (0.48) | GPR119HTR2AEGLN2KCNH2HSD17B10 | |
| SCHEMBL29388816 | 0.79 | KCNH2 (0.48) | GPR119HTR2AEGLN2KCNH2HSD17B10 | |
| SCHEMBL6619506 | 0.78 | EPHX2 (0.51) | GPR119HRH1HRH2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192155-B1 | NEW BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| US-6465481-B1 | EXHIBIT ELECTROPHYSIOLOGICAL ACTIVITY; MAY BE MORE POTENT AND PRODUCE FEWER SIDE EFFECTS INCLUDING LOWER INCIDENCE OF PROARRHYTHMIAS SUCH AS TORSADES DE POINTES | ASTRAZENECA AB (SE) | 2002-10-15 | — | — | US | disclosed |
| CN-1370166-A | Novel bispidine compounds useful in the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2002-09-18 | — | — | CN | disclosed |