Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.67 |
| ▸ | PLK1 | P53350 | 1/20 | 0.55 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.55 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.54 |
| ▸ | CHUK | O15111 | 1/20 | 0.54 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.54 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3067088 | 0.91 | LMNA (0.60) | LMNATHRBPLK1S1PR1S1PR3 | |
| SCHEMBL13415301 | 0.84 | L3MBTL1 (0.69) | LMNAPLK1KDM4ENPC1RAB9A | |
| SCHEMBL417374 | 0.84 | NPC1 (0.61) | LMNATHRBPLK1KDM4ENPC1 | |
| SCHEMBL25463239 | 0.82 | PLK1 (0.55) | LMNATHRBPLK1KDM4ENPC1 | |
| SCHEMBL15219436 | 0.80 | L3MBTL1 (0.70) | S1PR1KDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL22925912 | 0.80 | NOTUM (0.61) | LMNATHRBS1PR1S1PR3CHUK | |
| SCHEMBL2360966 | 0.79 | L3MBTL1 (0.58) | LMNAPLK1SIRT2NPC1RAB9A | |
| SCHEMBL2967349 | 0.79 | L3MBTL1 (0.62) | LMNAPLK1NPC1RAB9AL3MBTL1 | |
| SCHEMBL6979484 | 0.78 | LMNA (0.57) | LMNATHRBS1PR1S1PR3CHUK | |
| SCHEMBL24485887 | 0.78 | CA12 (0.49) | LMNATHRBPLK1S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183276-B2 | Therapeutic agents | MERCK SHARP & DOHME CORP. | 2012-05-22 | — | — | US | disclosed |
| US-20100324029-A1 | THERAPEUTIC AGENTS | MERCK SHARP & DOHME CORP. | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324029-A1 | THERAPEUTIC AGENTS | PSEN2, PSEN1, BACE2 | LMNA 1357/4885THRB 3278/4885PLK1 1830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.