Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986602 | 0.91 | KDM4E (0.41) | TSHRALDH1A1POLBKDM4EKMT2A | |
| SCHEMBL6985013 | 0.86 | KMT2A (0.39) | ALDH1A1POLBKDM4EKMT2AL3MBTL1 | |
| SCHEMBL6987065 | 0.86 | POLB (0.39) | ALDH1A1POLBKDM4EKMT2AL3MBTL1 | |
| SCHEMBL6977033 | 0.86 | KMT2A (0.38) | ALDH1A1POLBKDM4EKMT2AL3MBTL1 | |
| SCHEMBL6981559 | 0.85 | ADRA1B (0.41) | POLBKMT2AL3MBTL1 | |
| SCHEMBL6979427 | 0.84 | CYP2C19 (0.39) | ALDH1A1POLBKDM4EKMT2AL3MBTL1 | |
| SCHEMBL6985684 | 0.82 | ADRA1B (0.47) | L3MBTL1 | |
| SCHEMBL4877154 | 0.82 | TSHR (0.51) | TSHRALDH1A1POLBKDM4EKMT2A | |
| SCHEMBL6985829 | 0.80 | POLB (0.37) | ALDH1A1POLBKDM4EKMT2AL3MBTL1 | |
| SCHEMBL6985492 | 0.80 | POLB (0.38) | ALDH1A1POLBKDM4EKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090081-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-29 | — | — | WO | disclosed |