Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1B | P35368 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 5/20 | 0.40 |
| ▸ | BCHE | P06276 | 4/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981559 | 0.92 | ADRA1B (0.41) | ADRA1BL3MBTL1ACHEBCHECHRM2 | |
| SCHEMBL6979847 | 0.89 | ADRA1B (0.41) | ADRA1BL3MBTL1ACHEBCHE | |
| SCHEMBL6985013 | 0.88 | KMT2A (0.39) | ADRA1BL3MBTL1CHRM2CHRM1ADRA1A | |
| SCHEMBL6987065 | 0.88 | POLB (0.39) | ADRA1BL3MBTL1ACHEBCHEADRA1A | |
| SCHEMBL6978015 | 0.87 | MEN1 (0.39) | ADRA1BACHEBCHEADRA1AMC4R | |
| SCHEMBL6987748 | 0.87 | KCNH2 (0.41) | ADRA1BADRA1ASIGMAR1 | |
| SCHEMBL6977033 | 0.87 | KMT2A (0.38) | ADRA1BL3MBTL1ACHEBCHEADRA1A | |
| SCHEMBL6980148 | 0.86 | SMN1; SMN2 (0.43) | ADRA1BACHEBCHE | |
| SCHEMBL6981458 | 0.86 | SMN1; SMN2 (0.43) | ADRA1BACHEBCHE | |
| SCHEMBL6987894 | 0.86 | ADRA1B (0.37) | ADRA1BL3MBTL1ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090081-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-29 | — | — | WO | disclosed |