Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | AOC2 | O75106 | 2/20 | 0.34 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979427 | 0.93 | CYP2C19 (0.39) | POLBKMT2ATDP1ALDH1A1ADRA1B | |
| SCHEMBL6985013 | 0.92 | KMT2A (0.39) | POLBKMT2ATDP1ALDH1A1ADRA1B | |
| SCHEMBL6977033 | 0.91 | KMT2A (0.38) | POLBKMT2ATDP1ALDH1A1ADRA1B | |
| SCHEMBL6981559 | 0.90 | ADRA1B (0.41) | POLBKMT2ATDP1ADRA1BL3MBTL1 | |
| SCHEMBL6986602 | 0.88 | KDM4E (0.41) | POLBKMT2ATDP1ALDH1A1KDM4E | |
| SCHEMBL6985684 | 0.88 | ADRA1B (0.47) | ADRA1BADRA1AL3MBTL1BCHEACHE | |
| SCHEMBL6986401 | 0.86 | TSHR (0.48) | POLBKMT2AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL6985829 | 0.86 | POLB (0.37) | POLBKMT2ATDP1ALDH1A1ADRA1B | |
| SCHEMBL6985492 | 0.85 | POLB (0.38) | POLBKMT2ATDP1ALDH1A1ADRA1B | |
| SCHEMBL6987748 | 0.85 | KCNH2 (0.41) | ADRA1BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090081-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-29 | — | — | WO | disclosed |