Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 4/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.47 |
| ▸ | CCR6 | P51684 | 1/20 | 0.46 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16169793 | 0.85 | IMPDH2 (0.69) | IMPDH2CYP1A2CYP2C9MEN1KMT2A | |
| SCHEMBL17383846 | 0.85 | IMPDH2 (0.73) | IMPDH2CYP1A2CYP2C9MEN1KMT2A | |
| SCHEMBL27701196 | 0.82 | IMPDH2 (0.65) | IMPDH2CYP1A2CYP2C9MEN1KMT2A | |
| SCHEMBL4607984 | 0.82 | ESR1 (0.69) | IMPDH2CYP1A2CYP2C9MEN1KMT2A | |
| SCHEMBL8722197 | 0.82 | IMPDH2 (0.65) | IMPDH2CYP1A2CYP2C9MEN1KMT2A | |
| SCHEMBL27566954 | 0.79 | PTGS2 (0.62) | IMPDH2MEN1KMT2AAHRLMNA | |
| SCHEMBL8722153 | 0.79 | IMPDH2 (0.65) | IMPDH2CYP1A2CYP2C9MEN1KMT2A | |
| SCHEMBL31060312 | 0.79 | IMPDH2 (1.00) | IMPDH2CYP1A2CYP2C9MEN1KMT2A | |
| SCHEMBL28643376 | 0.78 | IMPDH2 (0.59) | IMPDH2CYP1A2CYP2C9MEN1KMT2A | |
| SCHEMBL14023506 | 0.78 | KMT2A (0.52) | IMPDH2CYP1A2CYP2C9MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303508-A1 | SUBSTITUTED 1-(4-AMINOPHENYL)INDOLES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | Boehringer Ingelheim Pharmaceuticals, Inc. (US) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002006273-A1 | SUBSTITUTED 1-(4-AMINOPHENYL)INDOLES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2002-01-24 | — | — | WO | disclosed |