Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 3/20 | 0.33 |
| ▸ | METAP1 | P53582 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6300344 | 0.75 | EPHX1 (0.33) | EPHX1METAP2METAP1 | |
| SCHEMBL6749608 | 0.68 | — | — | |
| SCHEMBL6986891 | 0.68 | — | — | |
| SCHEMBL5927952 | 0.65 | EPHX1 (0.65) | EPHX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5927948 | 0.65 | EPHX1 (0.65) | EPHX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7145927 | 0.64 | EPHX1 (0.31) | EPHX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7417604 | 0.63 | EPHX1 (0.33) | EPHX1ALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL5927975 | 0.63 | EPHX1 (0.61) | EPHX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7419722 | 0.62 | CTSS (0.47) | — | |
| SCHEMBL14895043 | 0.62 | EPHX1 (0.42) | EPHX1METAP2KMT2AALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362042-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057249-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |