Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6988161 | 0.84 | PTGS2 (0.43) | PTGS2KDM4EHSD17B10TDO2ALDH1A1 | |
| SCHEMBL6982952 | 0.79 | MAPK14 (0.39) | CCNA2CDK2CDK5CDK5R1PTGS2 | |
| SCHEMBL6981902 | 0.69 | MAPK9 (0.62) | CDK2CYP2C9MAPK9 | |
| SCHEMBL6986720 | 0.68 | MAPK9 (0.67) | MAPK9 | |
| SCHEMBL2666275 | 0.65 | KMO (0.48) | MAPK14KDM4EHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL11467792 | 0.64 | LMNA (0.58) | DYRK3CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL13692259 | 0.63 | ABL1 (0.58) | KDM4EHSD17B10ALDH1A1CYP1A2KMO | |
| SCHEMBL1720476 | 0.62 | PTGS2 (0.49) | CCNA2CDK2CDK5DYRK1ACDK5R1 | |
| SCHEMBL27779350 | 0.62 | KDM4E (0.51) | CCNA2CDK2CDK5DYRK1ACDK5R1 | |
| SCHEMBL1720026 | 0.62 | PTGS2 (0.49) | PTGS2LMNAKDM4EHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224180-B1 | SUBSTITUTED AZOLES | NOVARTIS AG (CH) | 2003-07-02 | — | — | EP | disclosed |
| US-6579874-B2 | P38 MAP kinase inhibitors; treating Tumor necrosis factor (TNF-alpha) and Interleukin-1 mediated diseases, such as rheumatoid arthritis; imidazole and oxazole derivatives | NOVARTIS AG (CH) | 2003-06-17 | — | — | US | disclosed |