Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1964500 | 0.73 | ALDH1A1 (0.58) | KMT2AL3MBTL1MEN1KDM4EPOLB | |
| SCHEMBL945418 | 0.72 | MAOB (0.48) | L3MBTL1KDM4EALDH1A1LMNA | |
| SCHEMBL36294 | 0.72 | GABRA1 (0.58) | L3MBTL1MGLLGABRA1GABRB2ALDH1A1 | |
| SCHEMBL29390847 | 0.72 | GABRA1 (0.58) | L3MBTL1MGLLGABRA1GABRB2ALDH1A1 | |
| SCHEMBL25425763 | 0.72 | GABRA1 (0.58) | L3MBTL1MGLLGABRA1GABRB2ALDH1A1 | |
| SCHEMBL13469225 | 0.72 | ALDH1A1 (0.61) | KMT2AMEN1KDM4EPOLBCRHBP | |
| SCHEMBL6446917 | 0.72 | GABRA1 (0.42) | L3MBTL1MGLLKDM4EGABRA1GABRB2 | |
| SCHEMBL949223 | 0.71 | TSHR (0.48) | KMT2AL3MBTL1MEN1ALDH1A1LMNA | |
| SCHEMBL8776692 | 0.71 | NCF1 (0.54) | ALOX5L3MBTL1MGLLALDH1A1 | |
| SCHEMBL1003778 | 0.70 | GABRA1 (0.47) | L3MBTL1SLC6A2SLC6A4MGLLKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294695-A2 | SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001085694-A2 | SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-11-15 | — | — | WO | disclosed |