Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 13/20 | 0.65 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990108 | 0.83 | TNFRSF1A (0.60) | TNFRSF1AKDM4EALDH1A1 | |
| SCHEMBL5575961 | 0.79 | TNFRSF1A (1.00) | TNFRSF1A | |
| SCHEMBL5575958 | 0.79 | TNFRSF1A (1.00) | TNFRSF1A | |
| SCHEMBL6988312 | 0.78 | TNFRSF1A (0.44) | TNFRSF1A | |
| SCHEMBL7121640 | 0.77 | TNFRSF1A (0.64) | TNFRSF1AMAPTHPGD | |
| SCHEMBL7124922 | 0.74 | TNFRSF1A (0.61) | TNFRSF1AHPGD | |
| SCHEMBL5576253 | 0.71 | TNFRSF1A (1.00) | TNFRSF1A | |
| SCHEMBL5576256 | 0.71 | TNFRSF1A (1.00) | TNFRSF1A | |
| SCHEMBL7062708 | 0.70 | TNFRSF1A (0.50) | TNFRSF1AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL5575701 | 0.70 | TNFRSF1A (1.00) | TNFRSF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1330448-A2 | 1,3-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND THEIR USE TO TREAT VCAM-1 MEDIATED DISORDERS | Atherogenics, Inc. (US) | 2003-07-30 | — | — | EP | claimed |
| WO-2001098291-A2 | 1,3-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND THEIR USE TO TREAT VCAM-1 MEDIATED DISORDERS | ATHEROGENICS, INC. (US) | 2001-12-27 | — | — | WO | claimed |