Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986523 | 0.90 | HTT (0.42) | TSHRHTTTDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6987595 | 0.90 | TDP1 (0.42) | HTTTDP1ALDH1A1SMN1; SMN2ADORA2B | |
| SCHEMBL6983758 | 0.90 | HTT (0.41) | LMNATSHRHTTTDP1ALDH1A1 | |
| SCHEMBL6986605 | 0.84 | HTT (0.48) | TSHRHTTALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6988597 | 0.84 | SIGMAR1 (0.53) | ADORA1 | |
| SCHEMBL6987183 | 0.80 | TSHR (0.45) | TSHRHTTALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL6988437 | 0.79 | ALDH1A1 (0.45) | LMNATSHRALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL6987611 | 0.79 | SIGMAR1 (0.44) | — | |
| SCHEMBL6987419 | 0.78 | ALDH1A1 (0.43) | TSHRHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL6990721 | 0.77 | SIGMAR1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313733-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018382-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-07 | — | — | WO | disclosed |