Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | JMJD1C | Q15652 | 1/20 | 0.32 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4745019 | 0.98 | GRM4 (0.39) | GRM4SORT1KDM4ELMNAPIK3C3 | |
| SCHEMBL6501033 | 0.77 | GRM4 (0.39) | GRM4SORT1KDM4ELMNAPIK3C3 | |
| SCHEMBL1578942 | 0.77 | KDM4E (0.53) | GRM4SORT1KDM4ELMNAKDM5A | |
| SCHEMBL7068952 | 0.76 | ALDH1A1 (0.33) | GRM4SORT1KDM4ELMNAPIK3C3 | |
| SCHEMBL27801110 | 0.75 | KDM4E (0.52) | GRM4SORT1KDM4ELMNAPIK3C3 | |
| Ammonia Solution, Strong SCHEMBL27766041 | 0.75 | KDM4E (0.52) | GRM4SORT1KDM4ELMNAPIK3C3 | |
| SCHEMBL14192611 | 0.75 | SORT1 (0.39) | GRM4SORT1KDM4ELMNAPIK3C3 | |
| SCHEMBL6989840 | 0.73 | CYP1A2 (0.37) | GRM4KDM4ELMNAPIK3C3ALDH1A1 | |
| SCHEMBL882664 | 0.72 | ALDH1A1 (0.47) | GRM4SORT1KDM4ELMNAPIK3C3 | |
| SCHEMBL2829062 | 0.71 | ADORA3 (0.41) | SORT1KDM4ELMNAKDM5AJMJD1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1093367-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1079821-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2001-08-29 | — | — | EP | disclosed |
| EP-1093367-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-25 | — | — | EP | disclosed |
| EP-1079821-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999066925-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-29 | — | — | WO | disclosed |
| WO-1999059570-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-25 | — | — | WO | disclosed |