Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | LGMN | Q99538 | 2/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837204 | 0.87 | TBXAS1 (0.38) | PDK1LIMK1TBXAS1ALDH1A1KMT2A | |
| SCHEMBL6992002 | 0.79 | PDK1 (0.48) | PDK1LIMK1LGMNMKNK1P2RX3 | |
| Hydrochloric Acid SCHEMBL6998122 | 0.78 | PDK1 (0.47) | PDK1LIMK1LGMNMKNK1P2RX3 | |
| Hydrochloric Acid SCHEMBL6998111 | 0.77 | PDK1 (0.46) | PDK1LIMK1LGMNMKNK1KDM4E | |
| SCHEMBL6989315 | 0.75 | PDK1 (0.51) | PDK1LIMK1LGMNKDM4EALDH1A1 | |
| SCHEMBL10680765 | 0.73 | NPC1 (0.41) | PDK1LIMK1LGMNKDM4EALDH1A1 | |
| SCHEMBL22070912 | 0.73 | NPC1 (0.41) | PDK1LIMK1LGMNKDM4EALDH1A1 | |
| SCHEMBL16038585 | 0.73 | GRM5 (0.43) | KDM4EALDH1A1GAAMAPTTSHR | |
| SCHEMBL17385025 | 0.70 | PDK1 (0.73) | PDK1LIMK1MKNK1P2RX3KDM4E | |
| SCHEMBL3630406 | 0.70 | KDM4E (0.50) | PDK1KDM4EALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927177-B1 | NOVEL BENZOTHIOPHENE DERIVATIVES, THEIR PREPARATION AND USE AS UROKINASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2003-11-26 | — | — | EP | disclosed |
| US-6274619-B1 | FUSED AMIDINO TYPE COMPOUNDS SUCH AS 4-(N-BUTYLCARBAMOYLMETHYLIDENE)-2-AMIDINO-4,5,6,7-TETRAHYDROBE NZO(B)THIOPHENE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-08-14 | — | — | US | disclosed |
| US-6093710-A | AN ENZYME INHIBITOR TREATING ANGIOGENESIS, ARTHRITIS, INFLAMMATION, METASTASIS, OSTEOPOROSIS, TUMORSANGIOGENESIS-DEPENDENT RETINOPATHIES, CONTRACEPTIVE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-07-25 | — | — | US | disclosed |