Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 4/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | ESRRG | P62508 | 2/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | ESRRB | O95718 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990344 | 0.92 | MEN1 (0.37) | MAPTCTSLOPRD1OPRK1LMNA | |
| SCHEMBL6985507 | 0.91 | SMN1; SMN2 (0.37) | CTSKTP53MAPTCTSLOPRD1 | |
| SCHEMBL6988090 | 0.91 | TP53 (0.35) | TP53MAPTOPRD1LMNARAB9A | |
| SCHEMBL6989542 | 0.90 | TP53 (0.40) | CTSKTP53THRBMAPTESRRG | |
| SCHEMBL6986649 | 0.89 | HTR1A (0.40) | CTSKTP53MAPTL3MBTL1LMNA | |
| SCHEMBL6991034 | 0.88 | TAS1R3 (0.34) | OPRD1OPRK1 | |
| SCHEMBL6988282 | 0.88 | TRPV1 (0.41) | CTSKCTSL | |
| SCHEMBL6989479 | 0.87 | ATM (0.39) | L3MBTL1LMNARAB9A | |
| SCHEMBL6990359 | 0.86 | HPGD (0.38) | THRBMAPTL3MBTL1CTSLLMNA | |
| SCHEMBL6988331 | 0.85 | KDM1A (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362042-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057249-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |