Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 18/20 | 0.41 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990344 | 0.90 | MEN1 (0.37) | TRPV1GPR139CTSL | |
| SCHEMBL6981853 | 0.90 | TRPV1 (0.42) | TRPV1 | |
| SCHEMBL6989479 | 0.90 | ATM (0.39) | — | |
| SCHEMBL6987228 | 0.88 | CTSK (0.37) | CTSLCTSK | |
| SCHEMBL6985507 | 0.88 | SMN1; SMN2 (0.37) | GPR139CTSLCTSK | |
| SCHEMBL6988090 | 0.87 | TP53 (0.35) | — | |
| SCHEMBL6986649 | 0.85 | HTR1A (0.40) | CTSK | |
| SCHEMBL6991034 | 0.85 | TAS1R3 (0.34) | — | |
| SCHEMBL6749648 | 0.83 | TRPV1 (0.45) | TRPV1CTSLCTSSCTSK | |
| SCHEMBL6990359 | 0.83 | HPGD (0.38) | CTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362042-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057249-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |