Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.39 |
| ▸ | PPARA | Q07869 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6988862 | 0.84 | PPARG (0.38) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL6220975 | 0.75 | KDM4E (0.42) | KMT2AMEN1KDM4ENPSR1PPARG | |
| SCHEMBL6705288 | 0.72 | TARBP2 (0.39) | NPC1RAB9AKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL5218987 | 0.71 | TARBP2 (0.42) | KMT2ASMN1; SMN2MEN1KDM4ENPSR1 | |
| SCHEMBL6703700 | 0.70 | TARBP2 (0.46) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| Ethane SCHEMBL5123686 | 0.69 | NPC1 (0.51) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL3151103 | 0.68 | ALDH1A1 (0.48) | MAPTSMN1; SMN2KDM4EPOLBHDAC6 | |
| SCHEMBL3885748 | 0.67 | S1PR4 (0.43) | MAPTSMN1; SMN2KDM4ESLC9A1TSHR | |
| SCHEMBL11324926 | 0.67 | ALDH1A1 (0.45) | KMT2AMAPTSMN1; SMN2MEN1KDM4E | |
| SCHEMBL6236664 | 0.66 | ESR2 (0.45) | TSHRALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313716-A1 | OXAZOLYL-ARYLPROPIONIC ACID DERIVATIVES AND THEIR USE AS PPAR AGONISTS | ELI LILLY AND COMPANY (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002016331-A1 | OXAZOLYL-ARYLPROPIONIC ACID DERIVATIVES AND THEIR USE AS PPAR AGONISTS | ELI LILLY AND COMPANY (US) | 2002-02-28 | — | — | WO | disclosed |