Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7382762 | 0.81 | PREP (0.48) | GAANPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL7367008 | 0.79 | PREP (0.48) | GAANPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL8539666 | 0.77 | MEN1 (0.43) | NPC1TDP1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL24641500 | 0.75 | SMN1; SMN2 (0.59) | GAAHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6646692 | 0.75 | DPP7 (0.45) | GAASMN1; SMN2KMT2AALDH1A1STS | |
| SCHEMBL8526553 | 0.74 | SIGMAR1 (0.59) | OPRM1SIGMAR1KMT2AALDH1A1KDM4E | |
| Benzylamine SCHEMBL8028466 | 0.74 | STS (0.51) | GAASMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL4713703 | 0.73 | HPGD (0.50) | NPC1TDP1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL24641798 | 0.73 | GPR119 (0.50) | GAAHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL30017169 | 0.73 | GPR119 (0.50) | GAAHTTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289957-A1 | PHARMACEUTICALLY ACTIVE PIPERIDINE DERIVATIVES, IN PARTICULAR AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001087839-A1 | PHARMACEUTICALLY ACTIVE PIPERIDINE DERIVATIVES, IN PARTICULAR AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2001-11-22 | — | — | WO | disclosed |