Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817122 | 0.82 | GHSR (0.47) | SMN1; SMN2NPC1RAB9ASTSHTT | |
| SCHEMBL7382762 | 0.80 | PREP (0.48) | MEN1KMT2ANPSR1SMN1; SMN2NPC1 | |
| SCHEMBL7367008 | 0.79 | PREP (0.48) | MEN1KMT2ANPSR1SMN1; SMN2NPC1 | |
| Benzylamine SCHEMBL8028466 | 0.78 | STS (0.51) | MEN1KMT2ASMN1; SMN2STSGPR119 | |
| SCHEMBL7331294 | 0.77 | NPC1 (0.57) | NPSR1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL16372360 | 0.77 | OPRD1 (0.42) | RAB9ATACR1CYP2C19GPR119 | |
| SCHEMBL6987676 | 0.77 | GAA (0.50) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL24859872 | 0.77 | TACR1 (0.52) | MEN1KMT2ASMN1; SMN2TACR1STS | |
| SCHEMBL7334052 | 0.76 | ALDH1A1 (0.51) | KMT2ASMN1; SMN2TDP1GRM5MAPK1 | |
| SCHEMBL7366153 | 0.76 | KDM4E (0.46) | KMT2ASMN1; SMN2LMNATDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861244-A1 | AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997018201-A1 | AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1997-05-22 | — | — | WO | disclosed |