Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PDE2A | O00408 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PDE9A | O76083 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998132 | 0.92 | CCNE2 (0.43) | GAAATMSMN1; SMN2KDM4ECYP3A4 | |
| SCHEMBL1961181 | 0.87 | ALDH1A1 (0.42) | GAAATMSMN1; SMN2KDM4ECYP3A4 | |
| SCHEMBL6987648 | 0.86 | PDE2A (0.47) | KDM4EKMT2APDE2AALDH1A1 | |
| SCHEMBL6996492 | 0.82 | PDE2A (0.47) | PDE2A | |
| SCHEMBL6998591 | 0.80 | PDE2A (0.45) | GAAKDM4EKMT2APDE2ALMNA | |
| SCHEMBL7352650 | 0.79 | ALDH1A1 (0.43) | GAAATMSMN1; SMN2KDM4ECYP3A4 | |
| SCHEMBL4947310 | 0.79 | PDE2A (0.62) | PDE2A | |
| SCHEMBL7885924 | 0.79 | CCNE2 (0.43) | GAAATMSMN1; SMN2KDM4ECYP3A4 | |
| SCHEMBL6997188 | 0.77 | CCNE2 (0.52) | KDM4EKMT2APDE2AALDH1A1 | |
| SCHEMBL6991547 | 0.77 | PDE2A (0.49) | KDM4EKMT2APDE2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973774-B1 | 1,5-DIHYDRO-PYRAZOLO 3,4-D]-PYRIMIDINONE DERIVATIVES | BAYER AG (DE) | 2003-01-22 | — | — | EP | disclosed |