Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985684 | 0.87 | ADRA1B (0.47) | SIGMAR1ADRA1BADRA1A | |
| SCHEMBL6987065 | 0.85 | POLB (0.39) | ADRA1BADRA1A | |
| SCHEMBL6985013 | 0.85 | KMT2A (0.39) | ADRA1BADRA1A | |
| SCHEMBL6977033 | 0.85 | KMT2A (0.38) | ADRA1BADRA1A | |
| SCHEMBL6981559 | 0.84 | ADRA1B (0.41) | ADRA1B | |
| SCHEMBL6978015 | 0.83 | MEN1 (0.39) | SIGMAR1ADRA1BADRA1A | |
| SCHEMBL6979427 | 0.83 | CYP2C19 (0.39) | ADRA1BADRA1A | |
| SCHEMBL6980148 | 0.82 | SMN1; SMN2 (0.43) | ADRA1B | |
| SCHEMBL6981458 | 0.82 | SMN1; SMN2 (0.43) | ADRA1B | |
| SCHEMBL6986602 | 0.81 | KDM4E (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090081-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-29 | — | — | WO | disclosed |