Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8404486 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2CYP1A2CYP2A6FFAR1MCL1 | |
| SCHEMBL6993650 | 0.79 | CYP1A2 (0.44) | SMN1; SMN2CYP1A2CYP2A6SSTR4CYP17A1 | |
| SCHEMBL30917304 | 0.76 | ENPP3 (0.33) | SMN1; SMN2CYP1A2CYP2A6ALDH1A1CYP17A1 | |
| SCHEMBL4572282 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2CYP1A2CYP2A6FFAR1MCL1 | |
| SCHEMBL1759529 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2CYP1A2CYP2A6FFAR1MCL1 | |
| SCHEMBL6992242 | 0.76 | ALDH1A1 (0.51) | SMN1; SMN2CYP1A2CYP2A6ALDH1A1MEN1 | |
| SCHEMBL14830422 | 0.74 | CYP17A1 (0.66) | CYP1A2CYP17A1 | |
| SCHEMBL24663489 | 0.74 | SMN1; SMN2 (0.56) | SMN1; SMN2CYP1A2CYP2A6FFAR1MCL1 | |
| SCHEMBL12946371 | 0.73 | SMN1; SMN2 (0.47) | SMN1; SMN2CYP1A2CYP2A6FFAR1MCL1 | |
| SCHEMBL12426067 | 0.73 | SMN1; SMN2 (0.47) | SMN1; SMN2CYP1A2CYP2A6FFAR1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003675-B2 | 3,4-dihalogenoisothiazole derivative, and agricultural or horticultural plant disease-controlling agent | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2011-08-23 | — | — | US | disclosed |
| US-8003675-B2 | 3,4-dihalogenoisothiazole derivative, and agricultural or horticultural plant disease-controlling agent | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2011-08-23 | — | — | US | disclosed |
| WO-2010070822-A1 | SAFENERS FOR HERBICIDES, HERBICIDAL COMPOSITIONS WITH REDUCED CHEMICAL DAMAGE AND SAFENING METHOD USING SAME | クミアイ化学工業株式会社 (JP) | 2010-06-24 | — | — | WO | disclosed |
| US-20090240057-A1 | 3,4-Dihalogenoisothiazole Derivative, and Agricultural or Horticultural Plant Disease-Controlling Agent | KUMIAI CHEMICAL INDUSTRY CO., LTD. AND IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2009-09-24 | — | — | US | disclosed |
| US-20090240057-A1 | 3,4-Dihalogenoisothiazole Derivative, and Agricultural or Horticultural Plant Disease-Controlling Agent | KUMIAI CHEMICAL INDUSTRY CO., LTD. AND IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2009-09-24 | — | — | US | disclosed |
| EP-0779281-B1 | ISOXAZOLES | SANKYO CO (JP) | 2003-10-29 | — | — | EP | disclosed |
| US-6096771-A | ISOXAZOLE DERIVATIVES EXHIBITING EXCELLENT TYPE B AND TYPE A MONOAMINE OXIDASE INHIBITORY ACTIVITIES, THEREFORE USEFUL FOR PREVENTING PARKINSON'S DISEASE, DEPRESSION AND ALZHEIMER'S DISEASE | SANKYO COMPANY, LIMITED (JP) | 2000-08-01 | — | — | US | disclosed |
| US-5965591-A | MONOAMINE OXIDASE INHIBITOR; FOR PROPHYLAXIS AND TREATING PARKINSON'S DISEASE, DEPRESSION AND ALZHEIMER'S DISEASE | SANKYO COMPANY, LIMITED (JP) | 1999-10-12 | — | — | US | disclosed |
| EP-0779281-A1 | ISOXAZOLES | SANKYO COMPANY LIMITED (JP) | 1997-06-18 | — | — | EP | disclosed |
| EP-0353821-B1 | Antipsychotic 3-piperazinyl-benzazole derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-05-10 | — | — | EP | disclosed |
| US-5015740-A | Psychological disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-05-14 | — | — | US | disclosed |
| US-4957916-A | DISORDERS CONNECTED WITH DOPAMINE AND/OR SEROTONIN RELEASE | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-09-18 | — | — | US | disclosed |
| EP-0353821-A2 | Antipsychotic 3-piperazinyl-benzazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-02-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090240057-A1 | 3,4-Dihalogenoisothiazole Derivative, and Agricultural or Horticultural Plant Disease-Controlling Agent | CBR3, HDHD5, OSR1 | SMN1; SMN2 4617/4885CYP1A2 1873/4885CYP2A6 2350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.