Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 3/20 | 0.52 |
| ▸ | TGFBR1 | P36897 | 10/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994944 | 0.91 | TGFBR1 (0.51) | MAPK10TGFBR1MAPK14MEN1NPC1 | |
| SCHEMBL6998890 | 0.88 | TGFBR1 (0.55) | TGFBR1MAPK14MEN1NPC1RAB9A | |
| SCHEMBL413765 | 0.84 | TGFBR1 (0.52) | TGFBR1MAPK14MEN1NPC1RAB9A | |
| SCHEMBL18230394 | 0.81 | TGFBR1 (0.58) | TGFBR1MAPK14MEN1KMT2A | |
| SCHEMBL6994559 | 0.81 | TGFBR1 (0.44) | MAPK10TGFBR1MAPK14MEN1NPC1 | |
| SCHEMBL4036011 | 0.79 | TGFBR1 (0.63) | MAPK10TGFBR1MAPK14KCNH2MEN1 | |
| SCHEMBL7001195 | 0.79 | KDR (0.46) | MAPK10TGFBR1MAPK14MEN1KMT2A | |
| SCHEMBL5956505 | 0.76 | TGFBR1 (0.55) | TGFBR1MAPK14MEN1KMT2A | |
| SCHEMBL18236266 | 0.74 | TGFBR1 (0.60) | TGFBR1MAPK14MEN1NPC1RAB9A | |
| SCHEMBL415611 | 0.73 | TGFBR1 (0.52) | TGFBR1MAPK14NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1366047-A1 | THIAZOLE COMPOUNDS AS TGF-BETA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-12-03 | — | — | EP | claimed |
| WO-2002062793-A1 | THIAZOLE COMPOUNDS AS TGF-BETA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-08-15 | — | — | WO | claimed |
| EP-1366047-A1 | THIAZOLE COMPOUNDS AS TGF-BETA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-12-03 | — | — | EP | disclosed |
| WO-2002062793-A1 | THIAZOLE COMPOUNDS AS TGF-BETA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-08-15 | — | — | WO | disclosed |