Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 14/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998890 | 0.87 | TGFBR1 (0.55) | TGFBR1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL6994944 | 0.82 | TGFBR1 (0.51) | TGFBR1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL6987967 | 0.81 | MAPK10 (0.52) | TGFBR1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL7001195 | 0.78 | KDR (0.46) | TGFBR1MEN1KMT2AKDRMAPK14 | |
| SCHEMBL450076 | 0.74 | TGFBR1 (0.52) | TGFBR1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL4036011 | 0.73 | TGFBR1 (0.63) | TGFBR1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL7371664 | 0.72 | KDR (0.51) | AURKBCDC7AURKANPC1RAB9A | |
| SCHEMBL5956505 | 0.70 | TGFBR1 (0.55) | TGFBR1MEN1KMT2AMAPK14 | |
| SCHEMBL6834538 | 0.69 | TGFBR1 (0.47) | TGFBR1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL18236266 | 0.68 | TGFBR1 (0.60) | TGFBR1MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1366047-A1 | THIAZOLE COMPOUNDS AS TGF-BETA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-12-03 | — | — | EP | disclosed |
| WO-2002062793-A1 | THIAZOLE COMPOUNDS AS TGF-BETA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-08-15 | — | — | WO | disclosed |